PhD Project "Biogenesis and Degradation of the Endoplasmic Reticulum" (Schuck_2023) - Heidelberg University

Date: 01/09/2023

Application Deadline: 20/07/2023

Our lab investigates how cells ensure proper morphology and function of their endoplasmic reticulum (ER)

Cells are amazing architects. When they need to differentiate or adapt to stress, cells are able to radically remodel their organelles, enlarge or shrink them, and give them a variety of shapes. As a result, the same organelle can have very different morphologies in different cells and can thus carry out specialized functions. 

Our lab investigates how cells ensure proper morphology and function of their endoplasmic reticulum (ER). In particular, we want to understand the molecular mechanisms through which cells coordinate the biogenesis and degradation of ER. We tackle this intriguing cell biological question in both yeast and mammalian cells, and we explore processes such as ER stress signaling, ER morphogenesis and ER-selective autophagy. Ultimately, we want to apply our findings from model systems to fight diseases arising from ER dysfunction, including diabetes and certain types of cancer. 

For more information about our research and us, please visit https://www.bzh.uni-heidelberg.de/schuck

Personal qualifications: We are looking for someone who has a background in molecular biology, biochemistry or cell biology, is eager to elucidate molecular mechanisms underlying complex cellular processes, is willing to acquire whatever technical skill it takes to address a scientific question and enjoys working as part of a team.

Please submit your application exclusively through the HBIGS application system: http://www.hbigs.uni-heidelberg.de/main_application.html